Novel synthesis of aza-phthalimidine hydroxylactams
A novel and convenient synthetic route for preparing aza-phthalimidine hydroxylactams (5a-j) by N-bromosuccinimide (NBS) was developed. This method involved the substitution reactions of substrates (3a-j) with NBS via unstable intermediate bromides (4a-j) rapidly hydrolyzed into hydroxyl products in the course of the workup process. Copyright Taylor & Francis Group, LLC.