104613-44-7

Basic information

• Product Name: versicolactone B
• Synonyms: versicolactone B
• CAS NO: 104613-44-7
• Molecular Formula: C15H22 O3
• Molecular Weight: 0
• Mol File: 104613-44-7.mol

Chemical Properties

• Boiling Point: 420.5°Cat760mmHg
• Flash Point: 176.4°C
• Appearance: /
• Density: 1.064g/cm³
• Vapor Pressure: 7.87E-09mmHg at 25°C
• Refractive Index: 1.505
• CAS DataBase Reference: versicolactone B(CAS DataBase Reference)
• NIST Chemistry Reference: versicolactone B(104613-44-7)
• EPA Substance Registry System: versicolactone B(104613-44-7)

Safety Data

• Hazardous Substances Data: 104613-44-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H22O3/c1-9(2)12-6-4-10(3)13(16)7-5-11-8-14(12)18-15(11)17/h4,11-14,16H,1,5-8H2,2-3H3/b10-4+/t11-,12-,13+,14-/m1/s1

Upstream product

• 6790-85-8 (6R,7S)-(4Z,10E)-6-hydroxy-7-isopropenyl-10-methyl-4,10-cyclodecadiene-4-carboxylic acid lactone 

Downstream Products

• 1429483-89-5 C₂₅H₂₇F₃O₅ 
• 1429483-88-4 C₂₅H₂₇F₃O₅ 

Relevant articles and documents

Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type i Receptor

A germacrane sesquiterpenoid library containing 30 compounds (2-31) was constructed by structural modification of a major component aristolactone (1) from the traditional Chinese medicine Aristolochia yunnanensis. Compound 11 was identified as a promising anticardiac fibrosis agent by systematic screening of this library. 11 could inhibit the expression of fibronectin (FN), α-smooth muscle actin (α-SMA), and collagens in transforming growth factor β 1 (TGFβ1)-stimulated cardiac fibroblasts at a micromolar level and ameliorate myocardial fibrosis and heart function in abdominal aortic constriction (AAC) rats at 5 mg/kg dose. Mechanistic study revealed that 11 inhibited the TGFβ/small mother against decapentaplegic (Smad) signaling pathway by targeting TGFβ type I receptor (IC50 = 14.9 ± 1.6 nM). The structure-activity relationships (SARs) study indicated that the unsaturated ?-lactone ring and oxidation of C-1 were important to the activity. These findings may provide a new type of structural motif for future anticardiac fibrosis drug development.

Germacrene sesquiterpene compounds, and medicinal compositions, preparation method and application thereof

The invention belongs to the technical field of medicines and discloses germacrene sesquiterpene compounds, and medicinal compositions, a preparation method and application thereof. The structures ofthe germacrene sesquiterpene compounds, medicinally acce