Aryl H-phosphonates. 6. Synthetic studies on the preparation of nucleoside N-alkyl-H-phosphonamidates
Various approaches to the synthesis of nucleoside H-phosphonamidates have been investigated. Direct couplings of nucleoside H-phosphonates with amines have been hampered by extensive reactions of the condensing agents with amines. Preactivation of nucleos
Sobkowska, Anna,Sobkowski, Michall,Cieslak, Jacek,Kraszewski, Adam,Kers, Inger,Stawinski, Jacek
A NEW AND VERSATILE APPROACH TO THE PREPARATION OF VALUABLE DEOXYNUCLEOSIDE 3'-PHOSPHITE INTERMEDIATES
The easily accessible and crystalline monofunctional phosphitylating reagent bis-(diisopropylamino)chlorophosphine has been used for the synthesis of phosphoramidites and H-phosphonates of d-nucleosides and, also, the formation of 3'-5'-internucleotidic phosphonate bonds.
Marugg, J. E.,Burik, A.,Tromp, M.,Marel, G. A. van der,Boom, J. H. van
p. 2271 - 2274
(2007/10/02)
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