Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient
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(2008/06/13)
Novel 1-benzhydryl-4-cinnamylpiperazine derivatives, and pharmaceutical compositions comprising said compounds as active ingredient for treating a cerebrovascular disease
A 1-benzhydryl-4-cinnamylpiperazine derivative represented by the following formula (I) STR1 wherein R1 represents a hydrogen atom or a methoxy group, and R2 represents a hydrogen or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof. The compound (I) is prepared by selectively reducing the corresponding 1-benzhydryl-4-cinnamoylpiperazine derivative and optionally converting the product into its acid addition salt. The compound (I) is useful for treatment of cerebrovascular disease in a human.
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(2008/06/13)
Benzylpiperazine derivatives. VI. Design and syntheses of vinylogs of 1-benzyl-4-diphenylmethylpiperazine derivatives and their cerebral vasodilating activities
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Ohtaka,Kanazawa,Ito,Tsukamoto
p. 4124 - 4129
(2007/10/02)
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