- Asymmetric hetero-Diels-Alder reactions of alkenyldihydrooxazoles. Synthesis of oxazolo[3,2-c]pyrimidines and related compounds
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Alkenyldihydrooxazoles undergo a highly diastereoselective formal aza-Diels-Alder reaction with aryl and arenesulfonyl isocyanates to give oxazolo[3,2-c]pyrimidines. Depending on the substitution pattern of the alkenyldihydrooxazole, these compounds may then undergo addition of a second equivalent of the isocyanate to give either tetrahydrooxazoIo[3,2-c]pyrimidine-8-carboxamides or octahydroazeto[2,3-7]oxazolo[3,2c]pyrimidines. The second addition is sensitive to steric and electronic factors, and can be prevented in some cases. The Royal Society of Chemistry 1999.
- Elliott, Mark C.,Kruisvvijk, Elbertus
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