SOLVENT AND TEMPERATURE DEPENDENT REGIOSELECTIVE REACTIONS BETWEEN 2-CHLORO-6-CYANOPYRIDINE AND ALIPHATIC ALCOHOLS
Reaction of 2-chloro-6-cyanopyridine with aliphatic mono- and di-alcohols or ethylene glycols affords, depending on the reaction conditions, alkoxypyridines or imino ester pyridines or a mixture of both types of compounds.It is suggested that the product distribution is determined by the stability of an imidate anion formed as an intermediate.An improved synthesis of 2-chloro-6-cyanopyridine is also described.
Elman, Bjoern
p. 4941 - 4948
(2007/10/02)
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