- New Molecular Scaffolds for Fluorescent Voltage Indicators
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The ability to non-invasively monitor membrane potential dynamics in excitable cells like neurons and cardiomyocytes promises to revolutionize our understanding of the physiology and pathology of the brain and heart. Here, we report the design, synthesis, and application of a new class of fluorescent voltage indicators that make use of a fluorene-based molecular wire as a voltage-sensing domain to provide fast and sensitive measurements of membrane potential in both mammalian neurons and human-derived cardiomyocytes. We show that the best of the new probes, fluorene VoltageFluor 2 (fVF 2), readily reports on action potentials in mammalian neurons, detects perturbations to the cardiac action potential waveform in human induced pluripotent stem cell-derived cardiomyocytes, shows a substantial decrease in phototoxicity compared to existing molecular wire-based indicators, and can monitor cardiac action potentials for extended periods of time. Together, our results demonstrate the generalizability of a molecular wire approach to voltage sensing and highlight the utility of fVF 2 for interrogating membrane potential dynamics.
- Boggess, Steven C.,Gandhi, Shivaani S.,Miller, Evan W.,Siemons, Brian A.,Huebsch, Nathaniel,Healy, Kevin E.
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Read Online
- Organic compound and electronic element and electronic device comprising same
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The invention provides an organic compound and an electronic element and an electronic device thereof, and belongs to the technical field of organic electroluminescence. The organic compound has a structural formula shown 1, wherein the organic compound h
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Paragraph 0113; 0172-0176; 0178
(2021/11/26)
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- NOVEL COMPOUND AND ORGANIC ELECTROLUMINESCENT DIVICE INCLUDING THE SAME
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The present invention relates to a novel compound to which two phenyldimethylfluorene and arylamine is directly coupled and an organic electroluminescent device including the same, which forms a HOMO level which can easily inject and transport a positive
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- NOVEL COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE INCLUDING THE SAME
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The invention relates to a novel compound and an organic electroluminescent device including the same.
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- NOVEL ORGANIC COMPOUND, MATERIAL COMPRISING THE SAME FOR ORGANIC ELECTROLUMINESCENCE DEVICES, AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE MATERIAL
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The present invention provides a novel organic compound of General Formula 1, a material comprising the same for organic electroluminescence devices, and an organic electroluminescence device comprising the material. The organic compound of the present invention is useful in organic electroluminescence devices as a hole injection layer substance, a hole transport layer substance, an electron blocking layer substance, and an emission layer substance such as green and red phosphorescent host substance, and when used in the organic electroluminescence devices, can reduce the drive voltage, and increase the luminous efficiency, luminance, thermal stability, color purity and service life of the devices.
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Paragraph 0125-0128
(2017/05/31)
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- NOVEL ORGANIC COMPOUND, MATERIAL COMPRISING THE SAME FOR ORGANIC ELECTROLUMINESCENCE DEVICES, AND ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE MATERIAL
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The present invention provides a novel organic compound, a material comprising the same for organic electroluminescence devices, and an organic electroluminescence device comprising the material. The organic compound provided in the present invention is useful in organic electroluminescence devices as a hole injection layer material, a hole transport layer material, an electron blocking layer material, and an emission layer material such as green and red phosphorescent host material, and can reduce the drive voltage, and increase the luminous efficiency, luminance, thermal stability, color purity and service life of the devices.
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Paragraph 0100; 0101; 0102; 0103
(2017/05/20)
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- Fluorene derivative and its manufacturing method
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PROBLEM TO BE SOLVED: To provide a complex of a fluorene derivative and carbon that can obtain an electrode and an electrochemical element that achieve output characteristics and a high energy density, and to provide a manufacturing method of the same.SOLUTION: A fluorene derivative has a fluorene ring structure, and in formula (1), the combination of m and R in the formula is either one of (1) and (2), wherein (1) m=4, R=H, and (2) m=3-5, R=halogen (F, Cl, Br, I), CF, COOR(in the formula, R=CH, wherein n=1-4), CON(R)(in the formula, R=CH, wherein m=1-2) or SOCH.
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- DERIVATIVES OF 2-DIARYLAMINOFLUORENE AND ORGANIC ELECTRONIC COMPOUNDS CONTAINING THEM
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The present invention relates to certain fluorenes, to the use of the compounds in an electronic device, and to an electronic device comprising at least one of these compounds. The present invention furthermore relates to a process for the preparation of the compounds and to a formulation and composition comprising one or more of the compounds.
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- AROMATIC AMINE DERIVATIVE, AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME
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Provided is an aromatic amine derivative represented by the formula N(ArA) (ArB) (ArC) as an organic EL device material capable of reducing the driving voltage of an organic EL device, and improving its luminous efficiency and device lifetime. ArA represents the formula (II-1) or (II-2). La represents an arylene group or the like, Ara represents an aryl group or the like, and n represents 2 or 3. ArB represents the formula (III). Lb represents a single bond or the like, R1 and R2 each represent an alkyl group or the like, o and p each represent 0 to 3 or the like, X represents an oxygen atom or the like, and R3, R4 and R5 each represent an alkyl group or the like. Arc represents an aryl group, a heteroaryl group, or the formula (II-1), (II-2), or (III).
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- AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME
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There are provided an aromatic monoamine derivative having a fluorene structure-containing organic group and an aromatic hydrocarbon group-containing organic group, and an organic electroluminescent element containing an organic thin film layer composed of a single layer or plural layers while including at least a light emitting layer, the organic thin film layer being between a cathode and an anode, wherein at least one layer of the organic thin film layer, particularly a hole transport layer, contains the aromatic amine derivative alone or as a component of a mixture. An organic electroluminescent element which maintains high luminous efficiency even if exposed to a high temperature environment, and has a low driving voltage and a long emission lifetime, and an aromatic amine derivative capable of realizing the organic electroluminescent element are provided.
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Page/Page column 31
(2012/02/15)
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- AROMATIC AMINE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT ELEMENTS USING SAME
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Provided are an organic EL device material capable of reducing the driving voltage of an organic EL device and increasing the lifetime of the device as compared with a conventional organic EL device material, specifically an aromatic amine derivative represented by N(Ara)(Arb)(Arc), and an organic EL device using the material. [Ara is represented by the formula (II). (In the formula (II): La represents a single bond or an arylene group; R1 to R4 each represent an alkyl group, an aryl group, or the like, and R3's or R4's, or R3 and R4 may be bonded to each other to form a ring; and o represents 0 to 3 and p represents 0 to 4.) Arb is represented by the formula (III). (in the formula (III), X represents NRa, O, or S, and Ra and R5 to R7 each represent an alkyl group, an aryl group, or the like, and R5's, R6's, or R7's adjacent to each other, or R5 and R6 may be bonded to each other to form a ring; n represents 2 to 4 when X represents NRa, and represents 0 to 4 when X represents O or S; and q represents 0 to 3, r and s each independently represent 0 to 4.) Arc represents an aryl group, or is represented by the formula (III).]
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Page/Page column 119
(2012/07/03)
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- AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME
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Disclosed is a long-life organic EL device having high luminous efficiency even after storage at high temperatures. Also disclosed is an aromatic amine derivative which enables to realize such an organic EL device. The aromatic amine derivative is represented by the following general formula (1). (In the formula (1), Ar1 is represented by the general formula (2) below, and Ar2 is represented by the general formula (3) below.)
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Page/Page column 48
(2011/08/07)
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- AROMATIC AMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME
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An aromatic amine derivative having a specific structure. An organic electroluminescence device which is composed of one or more organic thin film layers sandwiched between a cathode and an anode, wherein at least one of the organic thin film layers especially a hole transporting layer, contains the aromatic amine derivative. The aromatic amine derivative has at least one substituted or unsubstituted dibenzofuran skeleton and at least one substituted or unsubstituted terphenylene skeleton. Because the molecules in the aromatic amine derivative hardly crystallize, organic electroluminescence devices improving their production yield and having prolonged lifetime are provided.
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Page/Page column 49
(2011/04/18)
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