- Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity
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Polyunsaturated fatty acid-derived monoglycerides were characterized from the marine brown alga Sargassum sagamianum, collected from Jeju Island, Korea. A new compound of this structural class was isolated and determined to be 1-octadecatetraenoyl glycerol, by combined spectroscopic methods. Based on the structures and bioactivity of these compounds, a series of monoglycerides were synthesized using glycerol and various fatty acids. Several compounds exhibited moderate to significant inhibition of phospholipase A2 and cyclooxygenase-2.
- Chang, Hyeun Wook,Jang, Kyoung Hwa,Lee, Doohyun,Kang, Hee Ryong,Kim, Tae-Yoon,Lee, Bong Ho,Choi, Byoung Wook,Kim, Sanghee,Shin, Jongheon
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- POLYUNSATURATED FATTY ACID MONOGLYCERIDES, DERIVATIVES, AND USES THEREOF
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The invention emcompasses polyunsaturated fatty acid monoglycerides and derivatives thereof, having the formulae (I), (II), (III) and (IV), pharmaceutically acceptable salts thereof, compositions thereof and processes of preparing said compounds. These compounds can be useful as cancer chemopreventive agents, cancer treating agents, or radioenhencers for radiotherapy of cancer, or for inhibiting tumor growth or cell proliferation, or reducing tumor growth.
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(2008/12/08)
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