- Rim-Differentiated C5-Symmetric Tiara-Pillar[5]arenes
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The synthesis of "rim-differentiated" C5-symmetric pillar[5]arenes, whose two rims are decorated with different chemical functionalities, has remained a challenging task. This is due to the inherent statistical nature of the cyclization of 1,4-
- Guo, Minjie,Wang, Xuemei,Zhan, Caihong,Demay-Drouhard, Paul,Li, Wenjiao,Du, Ke,Olson, Mark A.,Zuilhof, Han,Sue, Andrew C.-H.
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- Facile and chemoselective cleavage of allyl carboxylic ester utilizing NaBH4 in DMSO
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A new method for deprotection of allyl carboxylic ester has been observed by using the inexpensive reagent sodium borohydride in dimethyl sulfoxide (DMSO). Aliphatic and aromatic allyl carboxylic ester undergo deprotection smoothly. The allyl ester group can selectively deprotect better than phenol.
- Pawar, Bharati V.,Lokhande, Pradeep D.
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scheme or table
p. 2445 - 2453
(2009/12/06)
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- DIAMINOPROPANE DERIVED MACROCYCLES AS INHIBITORS OF BETA AMYLOID PRODUCTION
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There is provided a series of macrocyclic diaminopropanes of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, m, n, W, X, Y, Z and L as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
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Page/Page column 35
(2008/12/07)
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