Evaluation of 2′-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase
Ribonucleoside phosphonate analogues containing 2′-α-fluoro modifications were synthesized and their potency evaluated against HCV RNA polymerase. The diphosphophosphonate (triphosphate equivalent) adenine and cytidine analogues displayed potent inhibitio
Parrish, Jay P.,Lee, Sharon K.,Boojamra, Constantine G.,Hui, Hon,Babusis, Darius,Brown, Brandon,Shih, I-Hung,Feng, Joy Y.,Ray, Adrian S.,Mackman, Richard L.
p. 3354 - 3357
(2013/06/27)
2'-Fluoronucleoside phosphonates as antiviral agents
The present invention includes compounds and compositions of R-2′-fluoronucleoside phosphonates, as well as methods to treat HIV, HBV, HCV or abnormal cellular proliferation comprising administering said compounds or compositions.
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Page/Page column 25; 26
(2008/06/13)
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