- Efficient synthesis of functionalized 1,3-dihydroisobenzofurans from salicylaldehydes: Application to the synthesis of escitalopram
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An efficient synthesis of substituted 1,3-dihydroisobenzofurans is developed. In this novel route, o-aroylbenzaldehydes, as key intermediates, can be obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. The mild and general st
- Wang, Peng,Zhang, Rui,Cai, Jin,Chen, Jun-Qing,Ji, Min
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p. 549 - 552
(2014/05/06)
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- A versatile and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans
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(Chemical Equation Presented) A convenient, versatile, and regiospecific synthesis of functionalized 1,3-diarylisobenzofurans has been developed. It involves chemoselective addition of arylmagnesium reagents to the aldehyde function of o-aroylbenzaldehydes, themselves readily obtained by lead tetraacetate oxidation of N-aroylhydrazones of salicylaldehydes. Various functional groups, including nitro, iodo, or ester functionalities, have thus been positioned with complete regiospecificity on the 1,3-diphenylisobenzofuran backbone.
- Jacq, Jerome,Einhorn, Cathy,Einhorn, Jacques
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supporting information; experimental part
p. 3757 - 3760
(2009/07/01)
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