- MACROCYCLIC INDOLE DERIVATIVES USEFUL AS HEPATITIS C VIRUS INHIBITORS
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Inhibitors of HCV replication of formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein R1, R2, R4, R5, R6 and R7 have the meaning defined in the claims. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
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Page/Page column 47-48
(2010/04/03)
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- Reaction of 1,2-dibromoethane with primary amines: Formation of N,N′-disubstituted ethylenediamines RNH-CH2CH2-NHR and homologous polyamines RNH-[CH2CH2NR]n-H
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The reaction of primary amines RNH2 (R: Me, Et, iPr, tBu and Ph) with 1,2-dibromoethane gave N,N′-disubstituted ethylenediamines R-NH-CH2CH2-NH-R (1) in yields ranging from 10% (1a; R=Me) to 70% (1d, R=tBu; 1e, R=Ph). Pipe
- Denk, Michael K.,Krause, Mike J.,Niyogi, Debyani F.,Gill, Nachhattarpal K.
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p. 7565 - 7570
(2007/10/03)
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- Process for producing 1,3-dialkyl-2-imidazolidinone
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A novel bis-urea compound, preparation process of the compound, and preparation process of 1,3-dialkyl-2-imidazolidinone are disclosed and the disclosure provides a novel preparation process of 1,3-dialkyl-2-imidazolidinone and simultaneously enables effective utilization of N,N',N"-trialkyldiethylentriamine which lacks a large amount use and is desired to develop new application.
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- Synthesis and Protonation Behaviour of the Macrocyclic Ligand 1,4,7,13-Tetramethyl-1,4,7,10,13,16-hexaazacyclooctadecane and of its Bicyclic Derivative 4,7,10,17,23-Pentamethyl-1,4,7,10,13,17,23-heptaazabicyclopentacosane. A Potentiometric and 1H and 13C NMR Study
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The synthesis and characterization of the new macrocyclic ligand 1,4,7,13-tetramethyl-1,4,7,10,13,16-hexaazabicyclooctadecane (L) and of its bicyclic derivative 4,7,10,17,23-pentamethyl-1,4,7,10,13,17,23-heptaazabicyclopentacosane (L1) is reported.The basicity behaviour of both polyamines has been studied by potentiometry in 0,15 mol dm-3 NaClO4 solution at 298.15 K and the relevant protonation constants have been determined. 1H and 13C NMR spectroscopy of L and L1, at various pH values, allows the main features of the protonation patterns to be determined.
- Bencini, Andrea,Bianchi, Antonio,Garcia-Espana, Enrique,Fusi, Vieri,Micheloni, Mauro,et al.
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p. 1059 - 1065
(2007/10/02)
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- A synthetic route to poly-N,N'-dimethylethylenediamines
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A simple high yielding synthesis of poly-N,N'-dimethylethylenediamines has been achieved by the alkylation of readily available N-methylamine or N,N'-dimethylethylenediamine with N-methyl-N-(4-toluenesulphonyl)iodoethylamine.
- Tuladhar,D'Silva
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p. 2203 - 2206
(2007/10/02)
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