Monovalent and bivalent fibrin-specific MRI contrast agents for detection of thrombus
Probing in contrast: Four gadolinium-DTPA moieties (DTPA = diethylenetriaminepentaacetic acid) and two fibrin-specific cyclic peptides are linked by a compact triethylenetetraamine core (see scheme) to create a highly sensitive probe for molecular MR imaging of thrombosis. The contrast agent has a high molecular relaxivity, and the dual peptide construct provides five-fold higher fibrin affinity than the monovalent analogue. This bivalent probe showed significant specific thrombus uptake in an in vivo model of thrombosis. (Figure Presented).
Nair, Shrikumar A.,Kolodziej, Andrew F.,Bhole, Gandhali,Greenfield, Matthew T.,McMurry, Thomas J.,Caravan, Peter