Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds
Screening of the NCI diversity set of compounds has led to the identification of 5 (NSC-117199), which inhibits the protein tyrosine phosphatase (PTP) Shp2 with an IC50 of 47 μM. A focused library incorporating an isatin scaffold was designed a
Lawrence, Harshani R.,Pireddu, Roberta,Chen, Liwei,Luo, Yunting,Sung, Shen-Shu,Szymanski, Ann Marie,Yip, M. L. Richard,Guida, Wayne C.,Sebti, Sa?d M.,Wu, Jie,Lawrence, Nicholas J.
experimental part
p. 4948 - 4956
(2009/07/11)
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