Chiral (Macrocyclic) Sulfide- and Sulfide/Alkylamino-Containing Ligands for Nickel-Catalyzed Grignard Cross-Coupling Reactions
Some macrocycles that contain sulfide and/or amino linkages as coordination sites have been examined as ligands for the nickel-catalyzed cross-coupling of the Grignard reagent of 1-phenyl-1-chloroethane with vinyl vromide to provide (1-methyl-2-propenyl)b
Vriesema, Bindert K.,Lemaire, Marc,Buter, Jan,Kellogg, Richard M.
p. 5169 - 5177
(2007/10/02)
MACROCYCLES WITH SULFIDE AND AMINE BINDING SITES AS CHIRAL LIGANDS FOR NICKEL CATALYZED CROSS COUPLING OF A GRIGNARD REAGENT WITH VINYL BROMIDE
Syntethic routes to macrocycles derived from (S)-phenyl alanine and (S)-cysteine have been developed.The catalyzed coupling of the Grignard reagent of 1-chloro-1-phenylethane and vinyl bromide in the presence of these ligands proceeds usually in good yields and in enantiomeric excesse (e.e.) of up to 46percent.
Lemaire, Marc,Vrisema, Bindert K.,Kellogg, Richard M.
p. 3499 - 3502
(2007/10/02)
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