- Nitrate NO donor type hematoporphyrin derivative and preparation method and application thereof
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The invention relates to the field of medicinal chemistry, in particular to preparation of nitrate NO donor type hematoporphyrin derivatives and application of the nitrate NO donor type hematoporphyrin derivatives in preparation of antitumor drugs. According to the invention, hematoporphyrin is used as a lead compound, nitrate capable of generating NO is selected as an NO donor by utilizing a splicing principle, and is connected to hydroxyl and carboxyl of a molecular structure through a connecting group, the nitrate NO donor type hematoporphyrin derivatives are designed and synthesized, and have a wide application prospect in the field of antitumor drugs.
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Paragraph 0031-0033
(2021/04/14)
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- Preparation method of alkane brominated material
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The invention relates to a preparation method of an alkane brominated material. The preparation method comprises the following steps: adding alkane, a bromine-containing compound or elemental bromine,a catalyst and acid into a solvent; adding the solvent into a light-transmission reaction container under air or oxygen atmosphere; sealing; performing stirring reaction under constant pressure and light illumination conditions; then analyzing a nuclear magnetic yield, and performing extraction, drying, filtration, distillation under reduced pressure and column separation to obtain the alkane brominated material. Compared with the prior art, the preparation method disclosed by the invention has the advantages that by using low-cost and safe bromic salt as a bromine source, the air as an oxidizing agent and a nitrogen-containing reagent as the catalyst, reaction is carried out under the conditions of constant temperature and constant pressure, so that energy conservation and economy are realized, and the preparation method is convenient and safe to operate and is environmentally friendly.
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Paragraph 0064-0065
(2018/09/08)
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- Catalytic Bromination of Alkyl sp3C-H Bonds with KBr/Air under Visible Light
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Alkyl sp3C-H bonds of cycloalkanes and functional branch/linear alkanes have been successfully brominated with KBr using air or O2 as an oxidant at room temperature to 40 °C. The reactions are carried out in the presence of catalytic NaNO2 in 37% HCl (aq)/solvent under visible light, combining aerobic oxidations and photochemical radical processes. For various alkane substrates, CF3CH2OH, CHCl3, or CH2Cl2 is employed as an organic solvent, respectively, to enhance the efficiency of bromination.
- Zhao, Mengdi,Lu, Wenjun
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supporting information
p. 5264 - 5267
(2018/09/12)
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