105310-47-2

Basic information

• Product Name: (E)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride
• Synonyms: (E)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride;2-(aMinoMethyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide hydrochloride;(1R,2R)-2-(AMinoMethyl)-N,N-diethyl-1-phenylcyclopropanecarboxaMide hydrochloride;(E)-2-(aMinoMethyl)-N,N- two-1- phenylethylcyclopropanecarboxaMide hydrochloride;(±)-trans Milnacipran Hydrochloride;(1S,2S)-2-(Aminomethyl)-N,N-diethyl-1-phenyl-cyclopropanecarboxamide hydrochloride
• CAS NO: 105310-47-2
• Molecular Formula: C₁₅H₂₂N₂O*ClH
• Molecular Weight: 282.81
• Mol File: 105310-47-2.mol

Chemical Properties

• Boiling Point: 393 ºC at 760 mmHg
• Flash Point: 191.5 ºC
• Appearance: /
• Vapor Pressure: 2.19E-06mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: (E)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride(105310-47-2)
• EPA Substance Registry System: (E)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride(105310-47-2)

Safety Data

• Hazardous Substances Data: 105310-47-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
(E)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride is used as a research compound for the development of new pharmaceuticals, particularly for its potential as an analgesic agent. Its unique structure and properties make it a valuable tool in the discovery and optimization of novel pain-relieving drugs.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (E)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride is used as a lead compound for the design and synthesis of new therapeutic agents. Its cyclopropane ring and functional groups provide a versatile scaffold for the exploration of structure-activity relationships and the development of more potent and selective analgesics.
Used in Drug Discovery:
(E)-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide hydrochloride is employed as a starting point in drug discovery efforts, where its chemical properties and potential therapeutic effects are further investigated and optimized. The hydrochloride form of the compound facilitates its use in various assays and screens, aiding in the identification of promising drug candidates for pain management and other therapeutic applications.

InChI:InChI=1/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15-;/m0./s1

Synthetic route

trans-2-aminomethyl-1-phenyl-N,N-diethylcyclopropanecarboxamide (105310-27-8)

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 20℃; for 1h;

trans-2-aminomethyl-1-phenyl-N,N-diethylcyclopropanecarboxamide (105310-27-8) → trans-2-aminomethyl-1-phenyl-N,N-diethylcyclopropanecarboxamide hydrochloride (105310-47-2)

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 20℃; for 1h;

Upstream product

• 105310-27-8 trans-2-aminomethyl-1-phenyl-N,N-diethylcyclopropanecarboxamide 

Relevant articles and documents

A new approach towards 1-phenyl and 1-benzyl substituted 2-(aminomethyl)cyclopropanecarboxamides as novel derivatives of the antidepressant Milnacipran

2-(2-Cyano-2-phenylethyl)aziridines were converted into novel trans-2-aminomethyl-1-phenylcyclopropanecarboxamides via regiospecific ring opening and 3-exo-tet cyclisation, thus providing the first convenient entry into the trans-isomer of Milnacipran as a useful template for further derivatisation. Furthermore, unprecedented 2-aminomethyl-1- benzylcyclopropanecarboxamides have been synthesized using two different routes starting from 2-(2-cyanoethyl)aziridines, both involving α-benzylation with respect to the nitrile group and aziridine to cyclopropane ring transformation. The Royal Society of Chemistry 2009.