105331-00-8 Usage
Uses
Used in Oncology:
6-amino-5-azacytidine is utilized as a chemotherapeutic agent for the treatment of patients with acute myelogenous leukemia. It functions by inhibiting cell growth and interfering with the metabolism of purines, which are essential components of nucleic acids and cellular function. This interference leads to the disruption of cancer cell proliferation and contributes to the therapeutic effects against leukemia.
Additionally, 6-amino-5-azacytidine may be employed in research settings to study the mechanisms of action and potential applications in other cancer types, given its ability to modulate gene expression and cellular processes. Its derivative nature from 5-Azacytidine also allows for the exploration of its potential synergistic or alternative therapeutic effects in combination with other cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 105331-00-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,5,3,3 and 1 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 105331-00:
(8*1)+(7*0)+(6*5)+(5*3)+(4*3)+(3*1)+(2*0)+(1*0)=68
68 % 10 = 8
So 105331-00-8 is a valid CAS Registry Number.
105331-00-8Relevant articles and documents
SYNTHESIS; MOLECULAR CONFORMATION AND BIOLOGICAL ACTIVITY OF 6-AMINO-5-AZACYTIDINE
Piskala, Alois,Hanna, Naeem B.,Zajicek, Jaroslav,Cihak, Alois
, p. 2502 - 2511 (2007/10/02)
Reaction of N-ethoxycarbonylguanidine II with 2,3,5-tri-O-benzoyl-β-D-ribosyl isocyanate (II) afforded N-ethoxycarbonylamidinourea IV, which was cyclized by bis(trimethylsilyl)acetamide to the 6-ethoxy derivative VII.Ammono- and methanolysis of intermedia
