Disclosed herein are substituted piperazine late Na+ channel modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
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Page/Page column 35
(2009/01/24)
DEUTERATED PIPERAZINE DERIVATIVES AS ANTI-ANGINAL COMPOUNDS
This invention relates to novel compounds of formula A that partially inhibit fatty acid oxidation and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel compounds that are derivatives of ranolazine. This invention also provides compositions comprising one or more compound of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by partial fatty acid oxidation inhibitors, such as ranolazine. (Formula A), wherein at least one of Y or R comprises a deuterium atom.
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Page/Page column 23-24
(2008/12/08)
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