105590-97-4

Basic information

• Product Name: H-GLU(OBZL)-OTBU HCL
• Synonyms: H-GLU(OBZL)-OTBU HCL;H-L-GLU(BZL)-OTBU HCL;H-L-GLU(OBZL)-OTBU HCL;L-GLUTAMIC ACID ALPHA-T-BUTYL-DELTA-BENZYL DIESTER HYDROCHLORIDE;L-GLUTAMIC ACID ALPHA-T-BUTYL-GAMMA-BENZYL-DIESTER HYDROCHLORIDE;L-GLUTAMIC ACID GAMMA-BENZYL ESTER ALPHA-T-BUTYL ESTER;GLUTAMIC ACID(OBZL)-OTBU HCL;GLUTAMIC ACID ALPHA-TERT-BUTYL-GAMMA-BENZYL DIESTER HYDROCHLORIDE
• CAS NO: 105590-97-4
• Molecular Formula: C₁₆H₂₃NO₄*ClH
• Molecular Weight: 329.82
• Mol File: 105590-97-4.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• Solubility: DMSO, Methanol
• CAS DataBase Reference: H-GLU(OBZL)-OTBU HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-GLU(OBZL)-OTBU HCL(105590-97-4)
• EPA Substance Registry System: H-GLU(OBZL)-OTBU HCL(105590-97-4)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 105590-97-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
H-GLU(OBZL)-OTBU HCL is used as a building block for the synthesis of dynamic peptides, which are essential in the development of novel pharmaceuticals and bioactive compounds. Its unique structure allows for the creation of peptides with specific properties and functions, making it a valuable asset in drug discovery and design.
Used in Research and Development:
In the field of research and development, H-GLU(OBZL)-OTBU HCL is used as a key component in the synthesis of various peptide sequences. This enables scientists to explore the potential of these peptides in various applications, such as therapeutics, diagnostics, and drug delivery systems.
Used in Peptide Synthesis:
H-GLU(OBZL)-OTBU HCL is used as a versatile building block in the synthesis of a wide range of peptides. Its unique structure allows for the creation of peptides with specific properties, making it an indispensable tool in the development of new peptide-based therapies and applications.

Upstream product

• 1676-73-9 L-glutamic acid γ-benzyl ester 
• 115-11-7 isobutene 
• 540-88-5 acetic acid tert-butyl ester 

Downstream Products

• 1025029-48-4 5-benzyl 1-tert-butyl N-{[2-(trimethylsilyl)ethoxy]carbonyl}-L-glutamate 
• 862778-54-9 2-bis(tert-butoxycarbonylmethyl)aminopentanedioic acid 5-benzyl ester 1-tert-butyl ester 
• 536721-25-2 L-glutamic acid, N-(1-oxohexadecyl)-, 1-(1,1-dimethylethyl) ester 
• 1026987-94-9 (S)-5-(tert-butoxy)-4-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-5-oxopentanoic acid 
• 105608-12-6 (S)-2-{(S)-4-Benzyloxycarbonyl-2-[2-(2-{(S)-2-[((S)-1-benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-butyrylamino}-pentanedioic acid 5-benzyl ester 1-tert-butyl ester 
• 106496-85-9 (S)-2-[2-(2-{(S)-2-[((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-amino]-3-methyl-butyrylamino}-2-methyl-propionylamino)-2-methyl-propionylamino]-pentanedioic acid 5-benzyl ester 
• 105590-81-6 (S)-2-{2-[2-((S)-2-{[(S)-1-(4-Chloro-benzoyl)-pyrrolidine-2-carbonyl]-amino}-3-methyl-butyrylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-pentanedioic acid 1-tert-butyl ester 5-methyl ester 
• 105590-98-5 dimethyl N-(4'-chlorobenzoyl)-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-glutamate 

Relevant articles and documents

Preparation method of glutamic acid-5-benzyl ester-1-tert-butyl ester hydrochloride

A preparation method of glutamic acid-5-benzyl ester-1-tert-butyl ester hydrochloride mainly solves the problem of operation difficulty in the synthesis method of the prior arts. A technical scheme is as below: the preparation method of glutamic acid-5-benzyl ester-1-tert-butyl ester hydrochloride comprises the steps of: esterifying a starting material of glutamic acid with benzyl alcohol, and purifying to obtain glutamic acid 5-benzyl ester; conducting a transesterification reaction on glutamic acid 5-benzyl ester and tert-butyl acetate under catalysis to obtain glutamic acid-5-benzyl ester-1-tert-butyl ether; and finally controlling the atmosphere with ether hydrochloric acid to an acidic state to obtain the glutamate 5-benzyl-1-t-butyl ester hydrochloride. The product can be used for the field of peptide synthesis.

THE CHEMISTRY OF PEPTIDES RELATED TO METABOLITES OF TRICHODERMA SPP. 2. AN IMPROVED METHOD OF CHARACTERIZATION OF PEPTIDES OF 2-METHYLALANINE

4-Chlorobenzoylazide reacts with amino acid and peptide esters to give the 4-chlorobenzoyl derivatives in 60-90percent yield, at room temperature, without measurable racemization.The reaction also proceeds smoothly with hindered amines such as methyl 2-me