A formal [4 + 4] complementary ambiphile pairing reaction: A new cyclization pathway for ortho-quinone methides
A formal, one-pot [4 + 4] cyclization pathway for the generation of eight-membered sultams via in situ generation of an ortho-quinone methide (o-QM) is reported. The pairing of ambiphilic synthons in a complementary fashion is examined whereby o-fluorobenzenesulfonamides are merged with in situ generated o-QM in a formal [4 + 4] cyclization pathway to afford 5,2,1- dibenzooxathiazocine-2,2-dioxide scaffolds under microwave (mW) conditions. The method reported represents the first use of an o-QM in a formal hetero [4 + 4] cyclization.
Samarakoon, Thiwanka B.,Hur, Moon Y.,Kurtz, Ryan D.,Hanson, Paul R.
supporting information; experimental part
p. 2182 - 2185
(2010/07/15)
ARYL SULFONAMIDES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR
In one embodiment, compounds of the following structure are described, wherein R1 to R7 are described herein. Also provided are methods for preparing these compounds and methods of contraception; treating or preventing fibroids; trea
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Page/Page column 22
(2008/12/08)
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