- PD-1 inhibitor as well as preparation method and application thereof
-
The present invention relates to a compound represented by a formula I, racemates, stereoisomers, tautomers, isotope markers, nitrogen oxide, solvates, polymorphs, metabolites, esters, prodrugs or pharmaceutically acceptable salts thereof, a pharmaceutical composition containing the compounds, a preparation method and a medical use of the compounds, wherein the structure of the formula I is shownin the specification.
- -
-
Paragraph 0256-0258
(2021/03/31)
-
- Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase
-
Soluble guanylyl cyclase (sGC) is an ubiquitously expressed enzyme that generates the second messenger cGMP and hence, leads to a number of physiological responses including vasodilation, inhibition of platelet aggregation and neurotransmission. Whilst ma
- von Wantoch Rekowski, Margarete,Pyriochou, Anastasia,Papapetropoulos, Nektarios,St??el, Anne,Papapetropoulos, Andreas,Giannis, Athanassios
-
experimental part
p. 1288 - 1296
(2010/04/26)
-
- Metalloprotease inhibitors containing a heterocyclic moiety
-
The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-13 inhibiting compounds with a modified benzoxazine moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13 inhibitors.
- -
-
Page/Page column 17
(2008/12/08)
-