- Chroman Compound, Processes for Its Preparation, and Its Pharmaceutical Use
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The present invention provided a chroman compound, the method of its preparation and pharmaceutical applications. The compound are represented by formula (I) and its pharmaceutical salt, where in :x is for O or S; n is for 2, 3 or 4; R1 is 6-situ or 7-situ halogen, C1-4alkyl, C1-4alkyoxyl, benzyloxy, acylamino; R2 is nitrogen-containing pentatomic or hexahydric substituted heterocyclic ring. The compound is useful to prepare anti-arrhythmic drugs, the reaction conditions of the method are mild, the raw material are plenty and easy to be obtained, and the operation and post-treatment are simple.
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Page/Page column 19-20
(2008/06/13)
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- UNEXPECTED FORMATION OF CHROMAN-4-ONES DURING THE SYNTHESIS OF 4-HYDROXYMETHYL-2H-CHROMENES FROM 4-ARYLOXYBUT-2-YN-1-OLS
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The unexpected formation of chroman-4-ones by refluxing 4-aryloxybut-2-yn-1-ols in diethylaniline has been studied, 4-hydroxymethyl-2H-chromene and chroman-4-carboxaldehyde derivatives being estbalished as intermediates.
- Camps, P.,Lluch, M.A.,Climent, M.J.,Miranda, M.A.
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p. 2041 - 2042
(2007/10/02)
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