- DESFERRITHIOCIN ANALOGS AND USES THEREOF
-
Iron overload is associated with pathological conditions such as oxidative stress, transfusional iron overload, thalassemia, primary hemochromatosis, secondary hemochromatosis, diabetes, liver disease, heart disease, cancer, radiation injury, neurological
- -
-
Paragraph 00383
(2015/06/08)
-
- Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity profiles
-
Desferrithiocin (DFT, 1) is a very efficient iron chelator when given orally. However, it is severely nephrotoxic. Structure-activity studies with 1 demonstrated that removal of the aromatic nitrogen to provide desazadesferrithiocin (DADFT, 2) and introdu
- Bergeron, Raymond J.,Wiegand, Jan,Bharti, Neelam,McManis, James S.
-
p. 7090 - 7103,14
(2020/09/09)
-