POTENT ANALOGUES OF THE C-MYC INHIBITOR 10074-G5 WITH IMPROVED CELL PERMEABILITY
The present invention relates compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell. The compounds exhibit increased inhibitory activity against c-Myc relative to the known c-Myc inhibitor small-molecule benzofurazan N-([1,1′-biphenyl]-2-yl)-7-nitrobenzo[c][1,2,5]oxadiazol-4-amine (10074-G5).
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Paragraph 0161
(2014/10/16)
The Synthesis of Some Sterically Hindered Acridines and a High Pressure Methylation
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Acheson, R. Morrin,Birtwistle, David H.,Constable, Edward C.,Tester, Gordon G.,Whitehead, W. F.,Wyatt, Peter B.
p. 2367 - 2383
(2007/10/02)
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