Nucleophilic aromatic substitution using Et3SiH/cat. t-Bu-P4 as a system for nucleophile activation
A novel type of deprotonative arylation of nucleophiles was conducted using Et3SiH/cat. t-Bu-P4 and the powerful SNAr reactions of aryl fluorides were accomplished using alcohols and malonates as nucleophiles. The Royal Society of Ch
Ueno, Masahiro,Yonemoto, Misato,Hashimoto, Masahiro,Wheatley, Andrew E. H.,Naka, Hiroshi,Kondo, Yoshinori
Two new, efficient and simple routes using Heck-type reaction and intramolecular cyclization were developed for the synthesis of the naturally occurring cytotoxic alkaloid 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-1H-indole-3- carbaldehyde (bouchardatine).
Naik, Nilesh H.,Urmode, Tukaram D.,Sikder, Arun K.,Kusurkar, Radhika S.
p. 1112 - 1114
(2013/09/24)
MULTICYCLIC LONIDAMINE ANALOGS
The invention provides lonidamine analogs as well as methods of treating cancer and BPH.
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Page/Page column 79
(2008/06/13)
COPPER(I)-PROMOTED COUPLING REACTION OF ARYL HALIDES WITH SODIUM DIETHYLMALONATE
Copper(I)-promoted coupling reaction of aryl halides with sodium diethylmalonate occured smoothly in dioxane.The qualitative trends in the activity of copper(I) salt followed the order: CuBr > CuI > CuBF4(CH3CN)4 > CuCl.The activity was lowered in the presence of coordinating molecule such as acetonitrile, pyridine, NaI, phosphine, and sulfide.The reaction was generally applicable to aryl halides with various substituents.