Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation
Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors.
Tegley, Christopher M.,Viswanadhan, Vellarkad N.,Biswas, Kaustav,Frohn, Michael J.,Peterkin, Tanya A.N.,Chang, Catherine,Buerli, Roland W.,Dao, Jennifer H.,Veith, Henrike,Rogers, Norma,Yoder, Sean C.,Biddlecome, Gloria,Tagari, Philip,Allen, Jennifer R.,Hungate, Randall W.
scheme or table
p. 3925 - 3928
(2009/05/07)
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