Reaction-based indicator displacement assay (RIA) for the development of a triggered release system capable of biofilm inhibition
Here, a reaction-based indicator displacement hydrogel assay (RIA) was developed for the detection of hydrogen peroxide (H2O2) via the oxidative release of the optical reporter Alizarin Red S (ARS). In the presence of H2O2, the RIA system displayed potent biofilm inhibition for Methicillin-resistant Staphylococcus aureus (MRSA), as shown through an in vitro assay quantifying antimicrobial efficacy. This work demonstrated the potential of H2O2-responsive hydrogels containing a covalently bound diol-based drug for controlled drug release.
Patenall, Bethany L.,Williams?, George T.,Gwynne, Lauren,Stephens, Liam J.,Lampard, Emma V.,Hathaway, Hollie J.,Thet, Naing T.,Young, Amber E.,Sutton, Mark J.,Short, Robert D.,Bull, Steven D.,James, Tony D.,Sedgwick, Adam C.,Jenkins, A. Toby A.
The instant invention provides compounds of formula I which are JAK3 inhibitors. Specifically, the compounds of formula I are pyrrolo[2,3-d]pyrimidine derivative compounds. The instant invention also provides methods of treating JAK-mediated diseases such
-
Page/Page column 173
(2013/06/27)
More Articles about upstream products of 1056904-42-7