Novel heterocyclic compounds are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agent. Method of synthesis and use of such compounds are also described.
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Page/Page column 325
(2008/06/13)
Practical and regioselective halogenations of aromatic compounds using tetrabutylammonium peroxydisulfate
The halogenated aromatic compounds have been important intermediates for various synthetic methods. Electron-rich aromatic compounds were easily iodinated using tetrabutylammonium peroxydisulfate (1) and iodine in mild conditions with excellent yields. Bromination was achieved using 1 and bromine, and regioselective bromination of highly activated aromatic compounds was also achieved using 1 and lithium bromide in mild conditions with excellent yields. Copyright Taylor & Francis Inc.
Min, Young Park,Seung, Gak Yang,Kim, Yong Hae
p. 1235 - 1240
(2007/10/03)
Practical and regioselective brominations of aromatic compounds using tetrabutylammonium peroxydisulfate
Direct bromination of wide range of aromatic compounds substituted with electron donating groups such as methoxy, hydroxy, or amino groups have been achieved with high regioselectivity by the reaction with Br2 in the presence of tetrabutylammonium peroxydisulfate 1 under mild conditions in acetonitrile in excellent yields. The use of lithium bromide as a bromination reagent afforded high yields of monobromo compounds with complete regioselectivity under neutral and mild reaction conditions in acetonitrile.
Park, Min Young,Yang, Seung Gak,Jadhav, Vidyadhar,Kim, Yong Hae
p. 4887 - 4890
(2007/10/03)
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