- Effecient kinetic resolution of racemic amino aldehydes by oxidation with N-iodosuccinimide
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(Chemical Equation Presented) Selective recognition: The first efficient method for the kinetic resolution of racemic amino aldehydes (see scheme, PG=protecting group) is based on a copper(II)/(R,R)-Ph-BOX complex. The coordinated amino aldehydes were tra
- Minato, Daishirou,Nagasue, Yoko,Demizu, Yosuke,Onomura, Osamu
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supporting information; experimental part
p. 9458 - 9461
(2009/05/06)
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- Methods for the stereoselective synthesis of substituted piperidines
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One aspect of the present invention relates to methods of synthesizing substituted piperidines. A second aspect of the present invention relates to stereoselective methods of synthesizing substituted piperidines. The methods of the present invention will
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- Pyrrolidinic and piperidinic ring fission by conjugate elimination
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Treating N-substituted pyrrolidines and piperidines bearing an allylic chain α to the nitrogen with strong bases leads to the opening of the heterocycle and provides 1,3-dienes disubstituted with an alkoxy and an aminoalkyl chain. The effects of the base and the solvent have been studied, as well as the influence of the ring size and the nitrogen substituent. The results obtained suggest a possible pre-chelation of the base cation before the deprotonation.
- Acquadro, Francesco,Oulyadi, Hassan,Venturello, Paolo,Maddaluno, Jacques
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p. 8759 - 8763
(2007/10/03)
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- Src kinase inhibitor compounds
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Pyrimidine compounds (Formula I), or their pharmaceutically acceptable salts, hydrates, solvates, crystal forms and individual diastereomers, and pharmaceutical compositions including the same, which are inhibitors of tyrosine kinase enzymes, and as such are useful in the prophylaxis and treatment of protein tyrosine kinase-associated disorders, such as immune diseases, hyperproliferative disorders and other diseases in which inappropriate protein kinase action is believed to play a role, such as cancer, angiogensis, atheroscelerosis, graft rejection, rheumatoid arthritis and psoriasis.
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- The Synthesis of 1-Methyl-6,7,8,8a-tetrahydro-5H-indolizin-3-one by the Palladium-Catalyzed Cyclization of N-Bromoacetyl-2-vinylpiperidine
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N-Bromoacetyl-2-vinylpiperidine underwent cyclizalion to give indolizidine derivative in the presence of a base and a catalytic amount of palladium trifluoroacetate.
- Yang, Shyh-Chyun,Shea, Fang-Rong,Chung, Wen-Hung
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p. 293 - 296
(2007/10/03)
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- New synthesis of heterocycles by use of palladium catalyzed cycli zation of α-haloamide with internal double bond
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α-Haloamide having internal double bond was allowed to react with a catalytic amount of Pd(PPh3)4 in the presence of base to produce a cyclized product in a fairly good yield possibly through the intermediate of -alkylmetal complex. By use of this method, five and six membered lactams, pyrrolizidine and quinolizidine derivatives were synthesized in fairly good yields.
- Mori, Miwako,Kanda, Nana,Oda, Izumi,Ban, Yoshio
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p. 5465 - 5474
(2007/10/02)
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