cas 1057393-65-3, 2,3,5-trifluoro-4-iodopyridine

Articles about 1057393-65-3Total 3 be found

Synthesis of Polyflourinated Biphenyls; Pushing the Boundaries of Suzuki-Miyaura Cross Coupling with Electron-Poor Substrates
Polyfluorinated biphenyls are interesting and promising substrates for many different applications. Unfortunately, all current methods for the syntheses of these compounds only work for a hand full of molecules or only in very special cases. Thus, many of these compounds are still inaccessible to date. Here we report a general strategy for the synthesis of a wide range of highly fluorinated biphenyls. In our studies we investigated crucial parameters, such as different phosphine ligands and the influence of various nucleophiles and electrophiles with different degrees of fluorination. These results extend the scope of the already very versatile Suzuki-Miyaura reaction toward the synthesis of very electron-poor products, making these more readily accessible. The presented methodology is scalable and versatile without the need for elaborate phosphine ligands or Pd-precatalysts.
Bulfield, David,Huber, Stefan M.
p. 13188 - 13203
(2017/12/26)

Novel triazolopyridylbenzamides as potent and selective p38α inhibitors
A new class of p38α inhibitors based on a biaryl-triazolopyridine scaffold was investigated. X-ray crystallographic data of the initial lead compound cocrystallised with p38α was crucial in order to uncover a unique binding mode of the inhibitor to the hinge region via a pair of water molecules. Synthesis and SAR was directed towards the improvement of binding affinity, as well as ADME properties for this new class of p38α inhibitors and ultimately afforded compounds showing good in vivo efficacy.
Aiguadé, Josep,Balagué, Cristina,Carranco, Inés,Caturla, Francisco,Domínguez, María,Eastwood, Paul,Esteve, Cristina,González, Jacob,Lumeras, Wenceslao,Orellana, Adelina,Preciado, Sara,Roca, Ramón,Vidal, Laura,Vidal, Bernat
scheme or table
p. 3431 - 3436
(2012/06/18)

NEW 3-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-7-YL)BENZAMIDE DERIVATIVES
This invention is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.
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Page/Page column 44-45

(2008/12/07)