105746-37-0Relevant articles and documents
COMPOSITIONS AND METHODS FOR THE TREATMENT OF DIABETES
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, (2016/06/01)
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of fo
Synthesis and biological investigations of nitric oxide releasing nateglinide and meglitinide type II antidiabetic prodrugs: In-vivo antihyperglycemic activities and blood pressure lowering studies
Kaur, Jatinder,Bhardwaj, Atul,Huang, Zhangjian,Narang, Deepak,Chen, Ting-Yueh,Plane, Frances,Knaus, Edward E.
, p. 7883 - 7891 (2012/11/07)
A new group of hybrid nitric oxide-releasing type II antidiabetic drugs possessing a 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (13 and 18), 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (14 and 19), or nitrooxyethyl (15 and 20) moiety attached to the car
PROCESS FOR PRODUCTION OF CARBOXYLIC ACID CHLORIDE COMPOUND
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Page/Page column 8, (2009/01/24)
The present invention discloses methods for producing a carboxylic acid chloride compound which comprises the step of reacting an alkyl-substituted cyclohexyl carboxylic acid with a chlorinating agent in the presence of a specific urea compound. According to this invention, it is possible to produce a carboxylic acid chloride compound which has high reaction speed, and whose product has high purity or high yield. Thus produced carboxylic acid chloride compound is useful as an intermediate for producing D-phenylalanine derivatives which are used as agents for treating diabetes.
PROCESS FOR SYNTHESIZING HIGHLY PURE NATEGLINIDE POLYMORPHS
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Page/Page column 15-16, (2008/12/08)
The present invention relates to an improved process for synthesizing highly pure nateglinide of formula-(I). More particularly, the present invention relates to the process for synthesizing highly enantiomerically pure nateglinide form B and form H direc
PROCESS FOR PREPARING NATEGLINIDE B-TYPE CRYSTALS
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Page/Page column 11-12, (2008/06/13)
An improved process for preparing (-)-N-[(trans-4-isopropylcyclohexane)carbonyl]-D-phenylalanine of Formula I.
Process for the preparation of nateglinide, preferably in B-form
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Page/Page column 5; 6, (2008/06/13)
The present invention relates to a process for the preparation of nateglinide, preferably in B-form, substantially free from the H-form, comprising three steps starting from D-phenylalanine methyl ester or a salt thereof.
CRYSTALLINE FORM OF NATEGLINIDE AND PROCESS FOR PREPARATION THEREOF
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Page 19, (2008/06/13)
A new crystalline form of nateglinide (N-(trans-4-isopropylcyclohexanecarbonyl)D-phenylalanine) is provided. The new crystalline form is described by X-ray owder diffraction. Process for making the new crystalline form of nateglinide a e also provided.
NOVEL FORM OF N-(TRANS-4-ISOPROPYLCYCLOHEXYLCARBONYL)-D-PHENYLALANINE
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Page/Page column 7-8, (2010/02/07)
Novel polymorph Form C of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine is produced having different infra red spectrum and X-ray diffraction patterns from previously known forms of the compound.