MIXED GEM-DIMETALLIC ORGANIC COMPOUNDS. A NEW CLASS OF MULTI-COUPLING REAGENTS PART 2
The 1-magnesia-1-zincaalkene 4 and the 1-lithia-1-zincaalkene 15, easily obtained by a carbometallation reaction, are able to react successively with two different electrophiles to give good yields of various gem-difunctionalized compounds like the α-deuterated- and α-iodo- stannanes 7b-c and the α-allylated thioethers 10a-b.This demonstrates the usefulness of compounds type 4 and 15 as multi-coupling reagents.A new fragmentation reaction of alkylidene malonates is described.
Knochel, P.,Normant, J. F.
p. 1043 - 1046
(2007/10/02)
SYNTHESIS AND REACTIVITY OF GEM-DIMETALLIC ORGANIC COMPOUNDS. PART 1.
A number of gem-dimetallic compounds 4a-i have been prepared by carbometallation of an alkenyl organometallic derivative of Mg, Li or Al by an allylic zinc bromide.The 1-magnesia-1-zincaalkenes 4a-b react smoothly with various aldehydes in the presence of
Knochel, P.,Normant, J. F.
p. 1039 - 1042
(2007/10/02)
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