4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase
A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified.
Han, Qiang,Pabba, Praveen K.,Barbosa, Joseph,Mabon, Ross,Healy, Jason P.,Gardyan, Michael W.,Terranova, Kristen M.,Brommage, Robert,Thompson, Andrea Y.,Schmidt, James M.,Wilson, Alan G.E.,Xu, Xiaolian,Tarver, James E.,Carson, Kenneth G.
Synthesis of Pyrazolo[1,5-a]pyrimido[4,3-d]benzopyrans and 2-Pyrazolo [1,5-a]pyrimidinylphenols from the reaction of 5(3)-amino pyrazoles
A number of Pyrazolo[1,5-a]pyrimido[4,3-d]benzopyrans(4a-m) and 2-(Pyrazolo[1,5-a]pyrimidinyl)phenols (7a-k) have been prepared from the reaction of 5(3)-aminopyrazoles 3.