105851-18-1Relevant articles and documents
Fast production of highly reactive no-carrier-added [18F] fluoride for the labeling of radiopharmaceuticals
Lemaire, Christian F.,Aerts, Joel J.,Voccia, Samuel,Libert, Lionel C.,Mercier, Frederic,Goblet, David,Plenevaux, Alain R.,Luxen, Andre J.
, p. 3161 - 3164 (2010)
(Chemical equation presented) Doing without water: The 18F labeling of radiopharmaceuticals requires nearly anhydrous solutions of [ 18F]fluoride. Aqueous K2CO3 is generally used to elute [18F]fluorid
Accurate dispensing of volatile reagents on demand for chemical reactions in EWOD chips
Ding, Huijiang,Sadeghi, Saman,Shah, Gaurav J.,Chen, Supin,Keng, Pei Yuin,Kim, Chang-Jin,Van Dam, R. Michael
, p. 3331 - 3340 (2012)
Digital microfluidic chips provide a new platform for manipulating chemicals for multi-step chemical synthesis or assays at the microscale. The organic solvents and reagents needed for these applications are often volatile, sensitive to contamination, and wetting, i.e. have contact angles of 18F]FDG reliably. This journal is
SYSTEM FOR RADIOPHARMACEUTICAL PRODUCTION
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Page/Page column 41; 44, (2016/06/06)
Certain embodiments of the present invention relate to a system and a method for producing a radiopharmaceutical, wherein the system is formed from and/ or provides a microfluidic flow system. In certain embodiments, the system comprises a radioisotope isolation module, a radiopharmaceutical production module, a purification module and a quality control module.
DEVICE AND METHOD FOR THE PRODUCTION OF RADIOCHEMICAL COMPOUNDS
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Paragraph 0093-0094, (2015/05/26)
The invention relates to a device for the preparation of radiochemical compounds. It is provided that the device comprises at least a reaction module, a dosing module, and a storage module, wherein the reaction module has at least one reaction vessel having a closable opening through which substances needed for the preparation of a predetermined radiochemical compound can be introduced into the reaction vessel of the reaction module and through which the prepared radiochemical compound can be removed from the reaction vessel of the reaction module;the dosing module has at least one pipetting head which can be moved relative to the storage module and the reaction module and in x, y, and z directions and also has at least one dosing unit; andat least one reservoir for one of the substances needed for the preparation of the respective radiochemical compound is formed in the storage module.
DUAL RUN CASSETTE FOR THE SYNTHESIS OF 18F-LABELLED COMPOUNDS
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Page/Page column 15-17, (2015/06/03)
The invention provides a new chemical process, a new cassette configuration, and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F]-labelled PET tracer in the same day.
MODULAR RADIOCHEMISTRY SYNTHESIS SYSTEM
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Paragraph 0291-0295, (2016/01/15)
A modular chemical production system includes multiple modules for performing a chemical reaction, particularly of radiochemical compounds, from a remote location. One embodiment comprises a reaction vessel including a moveable heat source with the positi
DIGITAL MICROFLUIDIC PLATFORM FOR RADIOCHEMISTRY
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Paragraph 0106-0113, (2015/07/27)
Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18F.
Radiolabelling diverse positron emission tomography (PET) tracers using a single digital microfluidic reactor chip
Chen, Supin,Javed, Muhammad Rashed,Kim, Hee-Kwon,Lei, Jack,Lazari, Mark,Shah, Gaurav J.,Van Dam, R. Michael,Keng, Pei-Yuin,Kim, Chang-Jin C.J.
, p. 902 - 910 (2014/03/21)
Radiotracer synthesis is an ideal application for microfluidics because only nanogram quantities are needed for positron emission tomography (PET) imaging. Thousands of radiotracers have been developed in research settings but only a few are readily avail
System, device and method for preparing tracers and transferring materials during radiosynthesis
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Paragraph 0130-0131, (2014/11/13)
A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container a
3,4,6-Tri-O-acetyl-1,2-O-[1-(exo-ethoxy)ethyl-idene]-Β-d-manno- pyranose 0.11-hydrate
Liu, Ya-Ling,Zou, Pei,Wu, Hao,Xie, Min-Hao,Luo, Shi-Neng
, p. o338-o340 (2012/11/13)
The title compound, C16H24O10·0. 11H2O, is a key inter-mediate in the synthesis of 2-de-oxy-2-[ 18F]fluoro-d-glucose (18F-FDG), which is the most widely used mol-ecular-imaging probe for positron emission tomography (PET). The crystal structure has two independent mol-ecules (A and B) in the asymmetric unit, with closely comparable geometries. The pyran-ose ring adopts a 4 C 1 conformation [Cremer-Pople puckering parameters: Q = 0.553 (2) A?, = 16.2 (2)° and = 290.4 (8)° for mol-ecule A, and Q = 0.529 (2) A?, =15.3 (3)° and = 268.2 (9)° for mol-ecule B], and the dioxolane ring adopts an envelope conformation. The chiral centre in the dioxolane ring, introduced during the synthesis of the compound, has an R configuration, with the eth-oxy group exo to the manno-pyran-ose ring. The asymmetric unit also contains one water mol-ecule with a refined site-occupancy factor of 0.222 (8), which bridges between mol-ecules A and B via O - H?O hydrogen bonds.
