Side chain methyl substitution in the δ-opioid receptor antagonist TIPP has an important effect on the activity profile
The δ-opioid antagonist H-Tyr-Tic-Phe-Phe-OH (TIPP-OH) or its C- terminal amide analogue was systematically modified topologically by substitution of each amino acid residue by all stereoisomers of the corresponding β-methyl amino acid. The potency and se
Tourwé, Dirk,Mannekens, Els,Diem, Trang Nguyen Thi,Verheyden, Patricia,Jaspers, Hendrika,T?th, Géza,Péter, Antal,Kertész, Istvan,T?r?k, Gabriella,Chung, Nga N.,Schiller, Peter W.
p. 5167 - 5176
(2007/10/03)
ON THE SYNTHESIS OF METHYL (Z/E)-2-ACETAMIDO(OR BENZAMIDO)-3-ARYL 2-BUTENOATES
The methyl Z-2-acetamido(or benzamido)-3-aryl-2-butenoates (Z-9a-e, Z-10a-e) were obtained by two alternative procedures: stereospecific opening of Z-2-methyl(or phenyl)-4-(α-arylethylidene)-5(4H)-oxazolones (Z-7a-e, Z-8a-e) and stereospecific homologatio
Cativiela, C.,Villegas, M. D. Diaz de,Melendez, E.
p. 583 - 590
(2007/10/02)
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