Base-modified pyrimidine nucleosides. Efficient entry to 6-derivatized uridines by sn-pd transmetallation-coupling process
The palladium-catalyzed reaction of 6-tributylstannyluridine derivative 5 with a variety of aryl, vinyl, alkynyl, and allyl halides provides an efficient method for the synthesis of the corresponding cross-coupled products. In all cases, an enhancement on
6-Alkynylated uridines, a hitherto unknown class of compounds, were synthetized by a coupling reaction of terminal alkynes with 6-iodo-2',3'-O-isopropylidene-5'-O-methoxymethyluridine in the presence of bis(triphenylphosphine)palladium(II) chloride and co