Synthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes
The three-component Petasis borono-Mannich reaction starting with easily accessible N-protected α-amino aldehydes produces efficiently and diastereoselectively 1,2-trans-diamines with an enantiomeric excess of up to 98%.
Norsikian, Stéphanie,Beretta, Margaux,Cannillo, Alexandre,Martin, Amélie,Retailleau, Pascal,Beau, Jean-Marie
supporting information
p. 9991 - 9994
(2015/06/22)
β-TRIMETHYLSILYLETHANESULFONYL CHLORIDE (SES-Cl): A NEW REAGENT FOR PROTECTION OF AMINES
The title compound, easily prepared in two steps from vinyltrimethylsilane, is a useful reagent for the protection of primary and secondary amines as their sulfonamides, which are cleaved by fluoride ion.
Weinreb, Steven M.,Demko, Donald M.,Lessen, Thomas A.,Demers, James P.
p. 2099 - 2102
(2007/10/02)
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