1062054-75-4Relevant articles and documents
ALPHA-SUBSTITUTED N-SULFONYL GYLCINE AMIDES ANTAGONISTS OF CCR10, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR USING THEM
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Page/Page column 76, (2009/12/27)
Disclosed is a compound of formula (I). Wherein R1, R2 Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making t
Facile synthesis of ortho-halo-substituted 4-aryl-2-aminobutyric acids
Heim-Riether, Alexander
, p. 883 - 886 (2008/09/21)
Herein we describe an efficient and practical route for the regioselective synthesis of 4-(5-bromo/chloropyrazol-1-yl)-2-aminobutyric acids. The compounds have been prepared by regioselective C-5 halogenation of 1-(3,3-dimethoxypropyl) -1H-pyrazole followed by a Strecker synthesis. In addition, Boc-protected 2-amino-4-(2-chlorophenyl)butyric acid and 2-amino-4-(3-chloropyridin-2-yl) butyric acid have been synthesized. Georg Thieme Verlag Stuttgart.