- A new procedure for the phosphorylation of nucleosides: Application to the discovery of inhibitors of HIV integrase
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A new phosphorylating agent for nucleosides, 2-O-(4,4′-dimethoxytrityl) ethylsulfonylethan-2′-yl-phosphate (1), has been developed by us. In the many examples studied by us, phosphorylation yields were found to be very high (about 90%). The procedure appe
- Nair,Taktakishvili
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- A new method for the phosphorylation of nucleosides
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A new phosphorylating reagent, 2-O-(4,4'-dimethoxytrityl)ethylsulfonylethan-2'-yl-phosphate (1), was developed for the phosphorylation of primary and secondary alcohols of nucleosides. In the many examples studied, yields in the phosphorylation step were excellent (~80 to 95%). There is potential for wide applicability of this procedure, not only in nucleoside and nucleotide chemistry, but also in the phosphorylation of biomolecules such as carbohydrates and amino acids. (C) 2000 Elsevier Science Ltd.
- Taktakishvili,Nair
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p. 7173 - 7176
(2007/10/03)
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- A convenient method for removal of the t-butyl group from nucleoside bis(t-butyl) phosphates under non-acidic conditions
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A new method for selective removal of the t-butyl group from 3′ - bis(t-butyl) phosphate esters of 5′-0-(4,4′-dimethoxytrityl)deoxyribo-nucleosides was developed by use of Me3SiCl and Et3N. Several unexpected properties of the t-buty
- Sekine, Mitsuo,Iimura, Shin,Nakanishi, Takeshi
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p. 395 - 398
(2007/10/02)
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- Chemical Synthesis of 5'-Phosphorylated DNA Fragments and Their Constituents
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Phosphoryl tris-triazole has been applied to the synthesis of DNA fragments and their constituents bearing 5'-phosphomonoester function and to the preparation of deoxynucleoside 5'- or 3'-diphosphates.
- Jankowska, Jadwiga,Stawinski, Jacek
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