106362-66-7

Basic information

• Product Name: 4,5-DIMETHYL-2-IODOPHENOL
• Synonyms: 4,5-DIMETHYL-2-IODOPHENOL
• CAS NO: 106362-66-7
• Molecular Formula: C₈H₉IO
• Molecular Weight: 248.06
• Mol File: 106362-66-7.mol

Chemical Properties

• Boiling Point: 233.8 °C at 760 mmHg
• Flash Point: 95.2 °C
• Appearance: /
• Density: 1.74 g/cm³
• CAS DataBase Reference: 4,5-DIMETHYL-2-IODOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIMETHYL-2-IODOPHENOL(106362-66-7)
• EPA Substance Registry System: 4,5-DIMETHYL-2-IODOPHENOL(106362-66-7)

Safety Data

• Hazardous Substances Data: 106362-66-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4,5-DIMETHYL-2-IODOPHENOL is used as a reagent in organic synthesis for the preparation of a variety of compounds. Its unique structure allows it to participate in numerous chemical reactions, making it a valuable component in the synthesis of new organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 4,5-DIMETHYL-2-IODOPHENOL serves as a key intermediate in the synthesis of drugs. Its properties contribute to the development of medicinal compounds, potentially leading to new treatments and therapies.
Used in Dye and Pigment Production:
4,5-DIMETHYL-2-IODOPHENOL is also utilized as an intermediate in the production of dyes and pigments. Its chemical structure lends itself to the creation of colorants used in various applications, including textiles, plastics, and printing inks.
Used in Material Science:
Although not extensively detailed in the provided materials, 4,5-DIMETHYL-2-IODOPHENOL may have potential applications in material science. Its unique properties could be harnessed to develop new materials with specific characteristics for use in various industries.
Used in Research and Development:
4,5-DIMETHYL-2-IODOPHENOL is employed in research and development for new chemical compounds. Its involvement in scientific exploration aids in the discovery and innovation of novel substances with potential applications in multiple fields.

Upstream product

• 95-65-8 3,4-Dimethylphenol 
• 111726-44-4 4-Methoxymethoxy-1,2-dimethyl-benzene 

Downstream Products

• 666730-80-9 4-(2-iodo-4,5-dimethyl-phenoxy)-6,7-dimethoxy-quinoline 
• 111726-52-4 (E)-4-(2-Iodo-4,5-dimethyl-phenoxy)-but-2-enoic acid ethyl ester 

Relevant articles and documents

Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols

An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide as a cheap iodine atom source. A totally controlled monoiodination was achieved by buffering the reaction medium with K3PO4. This protocol proceeds with short reaction times, at mild temperatures, in an open flask, and generally with high yields. Gram-scale reactions, as well as the scope of this protocol, were explored with electron-rich and electron-poor phenols as well as heterocycles. Quantum chemistry calculations revealed PhII(OH)·NH3 to be the most plausible iodinating active species as a reactive "I+" synthon. In light of the relevance of the iodoarene moiety, we present herein a practical, efficient, and simple procedure with a broad functional group scope that allows access to the iodoarene core unit.

Gas-Chromatographic identifi cation of products formed in iodination of methyl phenols by retention indices

Iodination reaction followed by conversion of iodine-substituted methylphenols to the corresponding trifl uoroacetates was suggested for improving the sensitivity of the gas-chromatographic determination of phenol and its methyl-substituted derivatives (al isomers of mono- and diethylphenols, 2,3,5-, 2,3,6-, and 3,4,5-trimethylphenols) in aqueous media. Acylation products of iodo methylphenols (104 compounds) were identifi ed by linear-logarithmic retention indices on a standard nonpolar polydimethylsiloxane stationary phase, and the pattern of their variation with the number and nature of substituents were characterized. A procedure for identifi cation of methyl-substituted phenols in water in their gas-chromatographic determination with an electron-capture detector was developed. Pleiades Publishing, Ltd., 2012.

Structure Investigation of Xylenols and Their Redox Products by Thermal and Spectral Methods of Analyses

The structures of 2,6- and 3,4-xylenols together with their iodine redox products I-III were studied and critically investigated.Characterization of these materials involves elemental, thermogravimetric, differential thermogravimetric and differential the

Iodination of Phenols by Use of Benzyltrimethylammonium Dichloroiodate(1-)

The reaction of phenols with benzyltrimethylammonium dichloroiodate(1-) in dichloromethane-methanol in the presence of CaCO3 or NaHCO3 for several hours at room temperature gave iodophenols in good yields.

A general synthesis of dihydrobenzofurans by intramolecular conjugate addition

ortho Iodophenoxy crotonates 3e-7e cyclize to dihydrobenzofurans 1 and 9-12 when subjected to lithium-iodine exchange at -100 deg C.Naphtofuran 13 can be similarly obtained from α-iodonaphtoxy crotonate 8e.Methylation of this reaction mixture in