- An improved Pfitzinger reaction: Eco-efficient synthesis of quinaldine-4-carboxylates by TMSCl-mediated
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We report herein an improved Pfitzinger reaction for the synthesis of highly functionalized quinaldines from 1,3-dicarbonyl compounds, isatins and alcohols mediated by TMSCl. This synthesis involves cyclization and esterification in one-step cascade process for the formation of a carboxylate (CO2R) at the 4-position of quinaldine ring. Moreover, this procedure shows highly efficient, good functional group tolerance, operational simplicity, environment-friendly and feasibility of scale up.
- Lu, Lingling,Zhou, Pan,Hu, Biao,Li, Xiang,Huang, Rong,Yu, Fuchao
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supporting information
p. 3658 - 3661
(2017/08/23)
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- A simple one-pot synthesis of quinoline-4-carboxylic acid derivatives by Pfitzinger reaction of isatin with ketones in water
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An improved Pfitzinger condensation reaction performed under acidic conditions is established. It provides a simple and efficient synthetic method for some useful quinoline-4-carboxylic acid derivatives using isatins and ketones that cannot be obtained ea
- Lv, Qinghua,Fang, Lizhen,Wang, Pengfei,Lu, Chenjuan,Yan, Fulin
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p. 391 - 394
(2013/05/21)
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