Synthesis and evaluation of the anticonvulsant activity of 5-alkylthio-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives
A new series of 5-alkylthio-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives (4a-w) have been synthesized and tested for their anticonvulsant activity using the maximal electroshock (MES) test. The results indicated that all of the target compounds
Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-jun n-terminal kinase
We report comprehensive structure-activity relationship studies on a novel series of c-Jun N-terminal kinase (JNK) inhibitors. The compounds are substrate competitive inhibitors that bind to the docking site of the kinase. The reported medicinal chemistry
De, Surya K.,Stebbins, John L.,Chen, Li-Hsing,Riel-Mehan, Megan,Machleidt, Thomas,Dahl, Russell,Yuan, Hongbin,Emdadi, Aras,Barile, Elisa,Chen, Vida,Murphy, Ria,Pellecchia, Maurizio
experimental part
p. 1943 - 1952
(2009/12/30)
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