106515-46-2

Basic information

• Product Name: 1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol
• Synonyms: 1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol
• CAS NO: 106515-46-2
• Molecular Formula: C11H9N3OS
• Molecular Weight: 231.27366
• Mol File: 106515-46-2.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol(106515-46-2)
• EPA Substance Registry System: 1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol(106515-46-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 106515-46-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Applications:
1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol is used as a potential therapeutic agent for neurological disorders due to its studied pharmaceutical properties. Its antioxidant capabilities and potential to treat neurological conditions make it a compound of interest for further research and development in the medical field.
Used in Research Applications:
In the field of biological research, 1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol is used as a potential fluorescent tracer. Its ability to act as a tracer allows for its use in studying various biological processes and systems, contributing to a better understanding of cellular and molecular interactions.
Used in Antioxidant Applications:
As an antioxidant, 1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol is used to protect cells from oxidative stress and damage. Its antioxidant properties make it a candidate for use in the development of treatments for conditions associated with oxidative stress, such as neurodegenerative diseases.
Used in Chemical Synthesis:
1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol may also be used as a building block or intermediate in the synthesis of other complex organic compounds, particularly those with potential applications in the pharmaceutical, agrochemical, or materials science industries.
Further research is necessary to fully understand the potential applications and effects of 1-(1,3-benzothiazol-2-yl)-3-methyl-1H-pyrazol-5-ol, as well as to optimize its use in various industries.

Upstream product

• 20174-69-0 2-hydrazino-6-methylbenzothiazole 
• 257625-22-2 1-[5-hydroxy-3-methyl-1-(6-methyl-benzothiazol-2-yl)-1H-pyrazol-4-yl]-butane-1,3-dione 
• 851724-13-5 4-hydroxy-6-methyl-3-{1-[(6-methyl-benzothiazol-2-yl)-hydrazono]-ethyl}-pyran-2-one 
• 141-97-9 ethyl acetoacetate 
• 615-21-4 1,3-benzothiazol-2-ylhydrazine 

Downstream Products

• 106515-42-8 1-(2'-Benzothiazolyl)-3,4-dimethylpyrano<2,3-c>pyrazol-6(1H)-one 

Relevant articles and documents

Coordination of pyrazole-benzothiazole hybrids to the [ReO]3+ and fac-[Re(CO)3]+ cores

The reaction of the pyrazole-benzothiazole hybrids 2-(3,5-dimethylpyrazol-1-yl)benzothiazole (dmp) and 2-(2-benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol (Hbth) with [Re(CO)5Cl] resulted in the formation of neutral complexes with the general formula [ReCl(CO)3(HL)] (HL = dmp (1), Hbth (2)). 1-(Benzo[d]thiazol-2-yl)-4-methyl-1H-pyrrol-2-ol (Hbtm) gave the trimeric species [Re(btm)(CO)3]3 (3) by reaction with [Re(CO)5Cl]. Reaction with [ReVOCl3(PPh3)2] led to the isolation of the oxo-bridged dimeric compound (μ-O)[ReOCl2(dmp)]2 (4) and [ReOCl(bth)(bth1)] (5) [bth1 = 2-(benzo[d]thiazol-2-yl)-1,2,4,5,6,7-hexahydro-3H-indazol-3-one] by reaction with dmp and Hbth, respectively. The reactivity of Hbtm with trans-[ReOCl3(PPh3)2] in ethanol gave [ReOCl(btm)(btm1)] (6) [btm1 = 2-(benzo[d]thiazol-2-yl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one], whereas [ReOCl(btm1)(btz)] (7) [btz = 1-(benzo[d]thiazol-2-yl)-4-(1-iminoethyl)-3-methyl-1H-pyrazol-5ol] formed in acetonitrile using the same reactants. The rhenium(V) complexes [ReO(OMe)(btm)(btm1)] (8) and [ReO(OEt)0.96(I)0.04(btm)(btm1)] (9) were isolated upon reacting Hbtm with cis-[ReO2I(PPh3)2] in methanol and ethanol, respectively. The structures of complexes 1–9 were determined by X-ray diffraction methods and confirmed spectroscopically.

C-C bond cleavage studies in bipyrazoles: A convenient synthesis of pyrazolo-5-ols

The treatment of 4-acetoacetyl derivative (3) of the pyrazoles with hydrazines in ethanol/HCl furnished a variety of bipyrazoles (4). However, when the reaction was performed in sodium acetate/acetic acid/ethanol, different hydrazines gave different products. Under these conditions an unexpected C-C bond cleavage was observed thus affording a convenient route for the formation of pyrazolo-5-ols (5 and 6).