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CAS

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106515-92-8

1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-nitro-1H-indole is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 106515-92-8 Structure

  • Basic information

    1. Product Name: 1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-nitro-1H-indole
    2. Synonyms:
    3. CAS NO:106515-92-8
    4. Molecular Formula: C20H18FN3O2
    5. Molecular Weight: 351.3742
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 106515-92-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 452.3°C at 760 mmHg
    3. Flash Point: 227.3°C
    4. Appearance: N/A
    5. Density: 1.3g/cm3
    6. Vapor Pressure: 2.27E-08mmHg at 25°C
    7. Refractive Index: 1.646
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: 1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-nitro-1H-indole(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-nitro-1H-indole(106515-92-8)
    12. EPA Substance Registry System: 1-(4-fluorophenyl)-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-5-nitro-1H-indole(106515-92-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 106515-92-8(Hazardous Substances Data)

106515-92-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 106515-92-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,5,1 and 5 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 106515-92:
(8*1)+(7*0)+(6*6)+(5*5)+(4*1)+(3*5)+(2*9)+(1*2)=108
108 % 10 = 8
So 106515-92-8 is a valid CAS Registry Number.

106515-92-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-fluorophenyl)-3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitroindole

1.2 Other means of identification

Product number -
Other names Lu 22-135

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106515-92-8 SDS

106515-92-8Relevant articles and documents

Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles

Perregaard,Arnt,Bogeso,Hyttel,Sanchez

, p. 1092 - 1101 (2007/10/02)

A series of 1-(4-fluorophenyl)-1H-indoles substituted at the 3-position with 1-piperazinyl, 1,2,3,6-tetrahydro-4-pyridinyl, and 4-piperidinyl was synthesized. Within all three subseries potent dopamine D-2 and serotonin 5- HT2 receptor affinity was found in ligand binding studies. Quipazine-induced head twitches in rats were inhibited by most derivatives as a measure of central 5-HT2 receptor antagonism. Piperazinyl and tetrahydropyridyl indoles were cataleptogenic, while piperidyl substituted indoles surprisingly were found to be noncataleptogenic or only weakly cataleptogenic. Noncataleptogenic piperidyl derivatives also failed to block dopaminergic- mediated stereotypies, that is methyl phenidate-induced gnawing behavior in mice. These profiles resemble that of the atypical neuroleptic clozapine. 1- Ethyl-2-imidazolidinone was found to be the optimal substituent of the basic nitrogen atom in order to avoid catalepsy. The atypical neuroleptic 1-[2-[4- [5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2- imidazolidinone (sertindole, compound 14c) was selected for further development as a result of these structure/activity studies.

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