Stereoselective synthesis of syn-β-amino propargylic ethers: Application to the asymmetric syntheses of (+)-β-conhydrine and (-)-balanol
The stereoselective synthesis of syn-β-amino propargylic ethers by the addition of racemic lithio 3-(methoxymethoxy)allenylcuprates, and more particularly (cyano) and (mesityl)cuprates, to enantiopure chiral N-tert-butylsulfinylimines is reported. The sco
Concise syntheses of stereoisomeric hexahydroazepine derivatives related to the protein kinase inhibitor balanol
A stereodivergent route to four stereoisomeric azepane derivatives related to the important protein kinase inhibitor balanol is developed which utilises (-)- or (+)-serine as starting material, and a ring-closing metathesis as the key ring forming step.
Roy, Sankar P.,Chattopadhyay, Shital K.
p. 5498 - 5501
(2008/12/22)
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