106566-58-9 Usage
Uses
Used in Pharmaceutical Industry:
AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE is used as a therapeutic agent for its potential to inhibit AKT activity in leukemic cells. AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE has shown to have a favorable effect on renal pathologies in various animal models, making it a promising candidate for the treatment of diabetic nephropathy.
Used in Chemical Research:
AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE is utilized as a research compound in the field of chemistry, particularly for studying its chemical properties, reactivity, and potential applications in the synthesis of other compounds.
Used in Material Science:
In the field of material science, AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE is used as a component in the development of new materials with specific properties, such as improved conductivity, stability, or reactivity.
Biological Activity
Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1 α , IL-2 and TNF- α release.
references
[1] kalechman y, sredni b, weinstein t, et al. production of the novel mesangial autocrine growth factors gdnf and il-10 is regulated by the immunomodulator as101[j]. journal of the american society of nephrology, 2003, 14(3): 620-630.[2] kalechman y, gafter u, weinstein t, et al. inhibition of interleukin-10 by the immunomodulator as101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis association with dephosphorylation of stat3[j]. journal of biological chemistry, 2004, 279(23): 24724-24732.[3] sredni b, caspi r r, klein a, et al. a new immunomodulating compound (as-101) with potential therapeutic application[j]. nature, 1987, 330(6144): 173-176.[4] sredni b, albeck m, tichler t, et al. bone marrow-sparing and prevention of alopecia by as101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[j]. journal of clinical oncology, 1995, 13(9): 2342-2353.[5] kalechman y, gafter u, gal r, et al. anti-il-10 therapeutic strategy using the immunomodulator as101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[j]. the journal of immunology, 2002, 169(1): 384-392.
Check Digit Verification of cas no
The CAS Registry Mumber 106566-58-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,5,6 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 106566-58:
(8*1)+(7*0)+(6*6)+(5*5)+(4*6)+(3*6)+(2*5)+(1*8)=129
129 % 10 = 9
So 106566-58-9 is a valid CAS Registry Number.
106566-58-9Relevant articles and documents
REACTIONS OF TELLURIUM TETRAHALIDES WITH GLYCOLS
Zingaro, Ralph A.,Pathirana, Hema M. K. K.,Reibenspies, Joseph H.,Meyers, Edward A.
, p. 91 - 99 (2007/10/02)
Tellurium tetrahalides undergo reaction with glycols to yield three different products: O,O'-dioxotrihalotellurates; bis(alkoxy)dihalotellurium(IV) compounds and hexahalotellurates.The course of the reaction appears to be determined primarily by the natur
Synthesis and Properties of Ammonium Trichloro(dioxyethylene-O,O')tellurate (AS-101). A New Immunomodulating Compound
Albeck, M.,Tamari, T.,Sredni, B.
, p. 635 - 636 (2007/10/02)
Ammonium trichloro(dioxyethylene-O,O')tellurate(IV) (AS-101) was synthesized by refluxing tellurium(IV) chloride and ethylene glycol in acetonitrile, or by refluxing tellurium(IV) chloride and ammonium chloride in ethylene glycol.A mechanism for the reaction is suggested.X-ray data for AS-101 are given.Replacing ammonium chloride by potassium chloride yielded the potassium salt; however, with sodium chloride the sodium salt was not obtained.
