106577-39-3

Basic information

• Product Name: Hederacolchiside A1
• Synonyms: Hederacolchiside A1
• CAS NO: 106577-39-3
• Molecular Formula: C47H76O16
• Molecular Weight: 897.09674
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;reagent;standard substance;Triterpenoids
• Mol File: 106577-39-3.mol

Chemical Properties

• Melting Point: 253-255℃ (methanol , water )
• Boiling Point: 967.2±65.0 °C(Predicted)
• Appearance: /
• Density: 1.36±0.1 g/cm3 (20 ºC 760 Torr)
• PKA: 4?+-.0.70(Predicted)
• CAS DataBase Reference: Hederacolchiside A1(CAS DataBase Reference)
• NIST Chemistry Reference: Hederacolchiside A1(106577-39-3)
• EPA Substance Registry System: Hederacolchiside A1(106577-39-3)

Safety Data

• Hazardous Substances Data: 106577-39-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Hederacolchiside A1 is used as an anti-inflammatory agent for its ability to reduce inflammation, which can be beneficial in treating conditions characterized by excessive inflammation.
Used in Oncology:
Hederacolchiside A1 is used as an anti-cancer agent for its potential to inhibit the growth of cancer cells, offering a natural alternative or supplement to conventional cancer treatments.
Used in Drug Development:
Hederacolchiside A1 is used as a research compound for further exploration into its medicinal properties, with the aim of developing new drugs or therapies based on its anti-inflammatory and anti-cancer effects.
While the provided materials do not specify different applications in various industries, the potential uses mentioned above are inferred from the general properties of Hederacolchiside A1 as described. Further research would be necessary to determine specific applications in industries such as cosmetics, agriculture, or food science, should its properties align with the needs of those fields.

Related news

Hederacolchiside A1 (cas 106577-39-3) suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway07/31/2019

ObjectiveHederacolchiside A1, exhibits cytostatic and cytotoxic activity against various cancer cells in vitro, however, the mechanism is not well understood.detailed

Relevant articles and documents

Synthesis, biological evaluation and structure-activity relationship studies of hederacolchiside E and its derivatives as potential anti-Alzheimer agents

Inspired by the previously reported neuroprotective activity of hederacolchiside E (1), we synthesized hederacolchiside E for the first time along with eleven of its derivatives. The neuroprotective effects of these compounds were further evaluated agains

Synthesis and cytotoxicity of oleanolic acid trisaccharide saponins

An array of oleanolic acid-type saponins based on β-hederin has been synthesized in a linear or one-pot manner. The cell viability assays indicate that synthetic saponins show antiproliferation activities in three cancer cell lines with IC50 values of 2.4–15.1?μM and hederacolchiside A1 being the most potent. The results demonstrate that the type of terminal monosaccharides and linkage position have apparent effects on cytotoxicities and selectivities of these saponins against cancer cell lines tested. This study is helpful for future development of more potent anticancer leads.

Facile synthesis and cytotoxicity of triterpenoid saponins bearing a unique disaccharide moiety: hederacolchiside A1 and its analogues

An improved synthetic approach toward hederacolchiside A1, an antitumor triterpenoid saponin bearing a unique disaccharide moiety, was established. This approach began from a partially protected intermediate and avoided tedious protection-deprotection manipulation. An abnormal ring conformation (1C4) of the center arabinose residue was found in the intermediate, which may account for the unusual regioselectivity between 3-OH and 4-OH of arabinose. Two analogues of hederacolchiside A1 were then facilely prepared by this approach and exhibited significant cytotoxicity in preliminary in vitro assay.

Synthesis of β-hederin and Hederacolchiside A1: Triterpenoid saponins bearing a unique cytotoxicity-inducing disaccharide moiety

A facile synthetic approach toward oleanolic acid glycoside bearing α-l-rhamnopyranosyl-(1→2)-α-l-arabinopyranosyl moiety, a unique oligosaccharide that strongly induces antitumor activity of oleanane-type triterpenoid saponins, was developed. Based on th