106615-46-7

Basic information

• Product Name: 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine
• Synonyms: 1-(4,6-Dimethoxy-2-pyrimidinyl)piperazine;4,6-dimethoxy-2-(1-piperazinyl)Pyrimidine
• CAS NO: 106615-46-7
• Molecular Formula: C₁₀H₁₆N₄O₂
• Molecular Weight: 224.26
• Product Categories: pharmacetical
• Mol File: 106615-46-7.mol

Chemical Properties

• Boiling Point: 408.2°Cat760mmHg
• Flash Point: 200.7°C
• Appearance: /
• Density: 1.166g/cm³
• Vapor Pressure: 7.11E-07mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine(106615-46-7)
• EPA Substance Registry System: 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine(106615-46-7)

Safety Data

• Hazardous Substances Data: 106615-46-7(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine is used as a building block for the synthesis of pharmaceuticals and bioactive compounds due to its ability to interact with biological targets.
Used in Drug Development:
In the pharmaceutical industry, 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine is used as a precursor in the development of new drugs, leveraging its potential to bind with biological targets and contribute to the creation of novel therapeutic agents.
Further research and studies are needed to fully understand the potential uses and properties of 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine, as its applications in medicinal chemistry and drug development are still being explored.

InChI:InChI=1/C10H16N4O2/c1-15-8-7-9(16-2)13-10(12-8)14-5-3-11-4-6-14/h7,11H,3-6H2,1-2H3

Upstream product

• 110-85-0 piperazine 
• 113583-35-0 4,6-dimethoxypyrimidin-2-yl methyl sulfone 
• 13223-25-1 2-chloro-4,6-dimethoxypyrimidine 
• 223519-85-5 1-acetyl-4-(4,6-difluoropyrimidin-2-yl)piperazine 
• 90905-46-7 4,6-dimethoxy-2-(methylsulfanyl)pyrimidine 

Relevant articles and documents

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are novel heteroaryl compounds, pharmaceutically acceptable salts and pharmaceutical formulations thereof for selectively inhibiting serotonin reuptake and/or acting as 5-HT1A receptor agonists. Also provided herein are pharmaceutical compositions comprising the heteroaryl compounds and methods of using the pharmaceutical compositions in treating central nervous system (CNS) dysfunction in a mammal, especially a human being.

Design, Synthesis, Antifungal Activities and SARs of (R)-2-Aryl-4,5-dihydrothiazole-4-carboxylic Acid Derivatives

Based on the structure of natural product 2-aryl-4,5-dihydrothiazole-4-carboxylic acid, a series of novel (R)-2-aryl-4,5-dihydrothiazole-4-carboxylic acid derivatives were designed and synthesized. Their structures were characterized by 1H NMR, 13C NMR and HRMS. The single crystal structure of compound 9b was determined by X-ray diffraction analysis. The antifungal activities were evaluated for the first time. The bioassay results indicated that most compounds exhibited moderate to good antifungal activities. The antifungal activities of compound 13a (against Cercospora arachidicola Hori), 13d (against Alternaria solani), and 16e (against Cercospora arachidicola Hori) were 61.9%, 67.3% and 61.9%, respectively, which are higher than those of the commercial fungicides chlorothalonil and carbendazim. Moreover, compound 13d exhibited excellent antifungal activities against 7 kinds of the fungi tested (66.7%, 77.3%, 63.0%, 87.9%, 70.0%, 70.0% and 80.0% at 50 μg?mL). Therefore, 13d can be used as a new lead structure for the development of antifungal agents.

Synthesis and bioactivity of aripiprazole derivatives

Ten aripirazole (CAS 129722-12-9) derivatives were prepared and examined for dopamine receptor antagonist activity. The structures of these newly synthesized compounds were confirmed by their elemental analyses and by IR, 1H-NMR and mass spectra. It was demonstrated that all the new compounds have dopamine receptor antagonist activity to a certain extent. Three compounds showed more potent activity than aripiprazole. ECV · Editio Cantor Verlag.

Synthesis and biological activity of new 1-[4-(substituted)-piperazin-1- ylmethyl]-1H-benzotriazole

A new kind of benzotriazole derivatives has been designed and synthesised. The structures of all of the title compounds were characterised by 1H NMR, IR, MS and elemental analyses. Herbicidal activities of the benzotrizole derivatives were evaluated with barnyard grass and rape cup and KARI tests. The results showed that compounds exhibited weak herbicidal activities against barnyardgrass and rape and KARI enzyme.

Piperazine compounds and medicinal use thereof

The present invention relates to a piperazine compound of the formula wherein R1and R2are each hydrogen, halogen, lower alkyl, lower alkoxy, amino, substituted amino, nitro, hydroxy or cyano, R3, R4and R5are each hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, substituted amino or hydroxy, R6and R7are each hydrogen, lower alkyl, lower alkyl substituted by halogen, aralkyl, acyl or lower acyl substituted by halogen, R8and R9are each hydrogen or lower alkyl, Y is lower alkylene and the like, and ring A is phenyl, pyrimidyl, thiazolyl, pyridyl, pyrazyl or imidazolyl, a pharmaceutically acceptable salt thereof and pharmaceutical agents containing these compounds. The compound of the present invention has superior TNF-α production inhibitory effect and/or IL-10 production promoting effect, and, since it is free of or shows only strikingly reduced expression of an effect on the central nervous system, the compound is useful as a highly safe and superior TNF-α production inhibitor an/or IL-10 production promoter and is useful as an agent for the prophylaxis or treatment of various diseases caused by abnormal TNF-α production, diseases curable with IL-10, such as chronic inflammatory diseases, acute inflammatory diseases, inflammatory diseases due to infection, autoimmune diseases, allergic diseases, and TNF-α mediated diseases.

REMEDIES OR PREVENTIVES FOR AIDS

The present invention is to provide the combined use of one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor, and an AIDS therapeutic agent or preventive agent containing as its active ingredients one kind or two or more kinds of a quinolone carboxylic acid having anti-HIV activity and one kind or two or more kinds of a reverse transcriptase inhibitor or HIV protease inhibitor.

Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent

Disclosed are an aryl group- or heterocyclic group-substituted aminoquinolone compound represented by the formula (Ia), (Ib) or (Ic): STR1 wherein each of the substitutents are defined in the specification, or a salt of the compound, and an AIDS curing agent containing the same as an effective ingredient.

Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-b icyclo[2.2.1]heptanedicarboxime (Tandospirone) and related compounds

A series of cyclic imides bearing a ω-(4-aryl and 4-heteroaryl-1-piperazinyl)alkyl moieties was synthesized and tested in vivo for anxiolytic activity. The in vitro binding affinities of these compounds were also examined for 5-HT(1A) receptor sites. Structure-activity relationships within these series are discussed. One of these compounds, (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3- bicyclo[2.2.1]heptanedicarboximide (1: tandospirone), was found to be equipotent with buspirone in its anxiolytic activity and more anxio-selective than buspirone and diazepam. Tandospirone (1) is currently undergoing clinical evaluation as a selective anxiolytic agent.

Succinimide derivatives, and their production and use

A succinimide derivative of the formula: STR1 wherein R is a pyridyl or pyrimidinyl group substituted with at least one member selected from the group consisting of halogen, lower alkyl, lower alkoxy, cyano, benzyloxy, hydroxyl and amino, and n is an integer of 1 or 2, or a pharmaceutically acceptable acid addition salt thereof. The succinimide derivatives are useful as an anti-anxiety drugs.