106648-24-2Relevant articles and documents
Novel method for preparing donepezil
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, (2017/06/19)
The present invention relates to a method for preparing Donepezil, comprising the steps of: (a) making 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile represented by chemical formula 3 react with a benzylpiperidine compound represented by chemical formula 4 to provide 2-((1-benzylpiperidine-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile represented by chemical formula 2; and (b) subjecting 2-((1-benzylpiperidine-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile represented by chemical formula 2 to decyanation reaction, thereby providing Donepezil represented by chemical formula 1.COPYRIGHT KIPO 2017
Indene and naphthalene derivatives
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, (2008/06/13)
The invention relates to compounds of the general formula I STR1 wherein R1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO2, CF3 or the group --NR5 R6, whereby two substituents taken together may also represent a methylene-dioxy group, X represents a member selected from STR2 --CH2 --CH2 -- and --CH=CH--, n has the value 0, 1 or 2, R3 represents one of the moieties: STR3 and R2, R4, R5 and R6 represent hydrogen or alkyl(1-6 C), and pharmaceutically acceptable salts thereof, suitable in the treatment of heartfailure.